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Structure paper

TitleT cells control the generation of nanomolar-affinity anti-glycan antibodies.
Journal, issue, pagesJ. Clin. Invest., Vol. 127, Page 1491-1504, Year 2017
Publish dateMay 2, 2016 (structure data deposition date)
AuthorsPolonskaya, Z. / Deng, S. / Sarkar, A. / Kain, L. / Comellas-Aragones, M. / McKay, C.S. / Kaczanowska, K. / Holt, M. / McBride, R. / Palomo, V. ...Polonskaya, Z. / Deng, S. / Sarkar, A. / Kain, L. / Comellas-Aragones, M. / McKay, C.S. / Kaczanowska, K. / Holt, M. / McBride, R. / Palomo, V. / Self, K.M. / Taylor, S. / Irimia, A. / Mehta, S.R. / Dan, J.M. / Brigger, M. / Crotty, S. / Schoenberger, S.P. / Paulson, J.C. / Wilson, I.A. / Savage, P.B. / Finn, M.G. / Teyton, L.
External linksJ. Clin. Invest. / PubMed:28287405
MethodsX-ray diffraction
Resolution1.75 - 2.206 Å
Structure data

PDB-5jop:
Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-5jor:
Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A
Method: X-RAY DIFFRACTION / Resolution: 2.206 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / S. pneumoniae serotype 14 / anti-glycan B cells / synthetic conjugate vaccine / nanomolar affinity anti-glycan antibody / immune system-bacterial glycan complex

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