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TitleStructures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.
Journal, issue, pagesJ. Immunol., Vol. 196, Page 4723-4730, Year 2016
Publish dateOct 9, 2012 (structure data deposition date)
AuthorsBryson, S. / Thomson, C.A. / Risnes, L.F. / Dasgupta, S. / Smith, K. / Schrader, J.W. / Pai, E.F.
External linksJ. Immunol. / PubMed:27183571
MethodsX-ray diffraction
Resolution1.511 - 2.3 Å
Structure data

PDB-4hh9:
Anti-Human Cytomegalovirus (HCMV) Fab KE5
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4hha:
Anti-Human Cytomegalovirus (HCMV) Fab KE5 with epitope peptide AD-2S1
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4hie:
Anti-Streptococcus pneumoniae 23F Fab 023.102
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4hih:
Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4hii:
Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose-galactose
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4hij:
Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound L-rhamnose-(1-2)-alpha-D-galactose-(3-O)-phosphate-2-glycerol
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4ptt:
Crystal Structure of anti-23F strep Fab C05
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4ptu:
Crystal Structure of anti-23F strep Fab C05 with rhamnose
Method: X-RAY DIFFRACTION / Resolution: 1.511 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-RAM:
alpha-L-rhamnopyranose

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • human herpesvirus 5
KeywordsIMMUNE SYSTEM / Fab / Antibody / Fab fragment / Immunoglobin / Streptococcus pneumoniae 23F / 23F / Rhamnose

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