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Structure paper

TitleRegulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Journal, issue, pagesEmbo J., Vol. 35, Page 1133-, Year 2016
Publish dateNov 18, 2015 (structure data deposition date)
AuthorsForneris, F. / Wu, J. / Xue, X. / Ricklin, D. / Lin, Z. / Sfyroera, G. / Tzekou, A. / Volokhina, E. / Granneman, J.C. / Hauhart, R. ...Forneris, F. / Wu, J. / Xue, X. / Ricklin, D. / Lin, Z. / Sfyroera, G. / Tzekou, A. / Volokhina, E. / Granneman, J.C. / Hauhart, R. / Bertram, P. / Liszewski, M.K. / Atkinson, J.P. / Lambris, J.D. / Gros, P.
External linksEmbo J. / PubMed:27013439
MethodsX-ray diffraction
Resolution2.4 - 4.188 Å
Structure data

PDB-5fo7:
Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5fo8:
Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5fo9:
Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17)
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-5foa:
Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)
Method: X-RAY DIFFRACTION / Resolution: 4.188 Å

PDB-5fob:
Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-IOD:
IODIDE ION

Source
  • homo sapiens (human)
  • variola major virus
KeywordsLIPID BINDING / COMPLEMENT SYSTEM / IMMUNE SYSTEM / PLASMA PROTEIN / LIPID BIANDING / COFA ACTIVITY / REGULATORS OF COMPLEMENT ACTIVITY / LIPID BINDING PROTEIN / COFACTOR ACTIVITY / DECAY ACCELERATING ACTIVITY / DECAY-ACCELERATING ACTIVITY / IMMUNE EVASION

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