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TitleStructural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis
Journal, issue, pagesSci Rep, Vol. 6, Page 19681-19681, Year 2016
Publish dateSep 14, 2015 (structure data deposition date)
AuthorsYoun, H.-S. / Kim, T.G. / Kim, M.-K. / Kang, G.B. / Kang, J.Y. / Lee, J.-G. / An, J.Y. / Park, K.R. / Lee, Y. / Im, Y.J. ...Youn, H.-S. / Kim, T.G. / Kim, M.-K. / Kang, G.B. / Kang, J.Y. / Lee, J.-G. / An, J.Y. / Park, K.R. / Lee, Y. / Im, Y.J. / Lee, J.H. / Eom, S.H.
External linksSci Rep / PubMed:26805589
MethodsX-ray diffraction
Resolution2.6 - 3.09 Å
Structure data

PDB-5ayx:
Crystal structure of Human Quinolinate Phosphoribosyltransferase
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5ayy:
CRYSTAL STRUCTURE OF HUMAN QUINOLINATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH THE REACTANT QUINOLINATE
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

PDB-5ayz:
CRYSTAL STRUCTURE OF HUMAN QUINOLINATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH THE PRODUCT NICOTINATE MONONUCLEOTIDE
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NTM:
QUINOLINIC ACID

ChemComp-NCN:
NICOTINATE MONONUCLEOTIDE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / QUINOLINATE PHOSPHORIBOSYLTRANSFERASE / NAD BIOSYNTHESIS / NADC

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