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Structure paper

TitleStructural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page 596-601, Year 2016
Publish dateDec 9, 2015 (structure data deposition date)
AuthorsDevarkar, S.C. / Wang, C. / Miller, M.T. / Ramanathan, A. / Jiang, F. / Khan, A.G. / Patel, S.S. / Marcotrigiano, J.
External linksProc. Natl. Acad. Sci. USA / PubMed:26733676
MethodsX-ray diffraction
Resolution2.601 - 3.28 Å
Structure data

PDB-5f98:
Crystal structure of RIG-I in complex with Cap-0 RNA
Method: X-RAY DIFFRACTION / Resolution: 3.28 Å

PDB-5f9f:
Crystal structure of RIG-I helicase-RD in complex with 24-mer blunt-end hairpin RNA
Method: X-RAY DIFFRACTION / Resolution: 2.601 Å

PDB-5f9h:
Crystal structure of RIG-I helicase-RD in complex with 24-mer 5' triphosphate hairpin RNA
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-M7G:
7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE

ChemComp-ETF:
TRIFLUOROETHANOL

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-HOH:
WATER

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
  • synthetic construct (others)
Keywordshydrolase/rna / Complex / RIG-I / capped RNA / self versus non-self / innate immunity / hydrolase-rna complex

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