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TitlePolyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.
Journal, issue, pagesBiochemistry, Vol. 55, Page 704-714, Year 2016
Publish dateJan 15, 2016 (structure data deposition date)
AuthorsMori, S. / Simkhada, D. / Zhang, H. / Erb, M.S. / Zhang, Y. / Williams, H. / Fedoseyenko, D. / Russell, W.K. / Kim, D. / Fleer, N. ...Mori, S. / Simkhada, D. / Zhang, H. / Erb, M.S. / Zhang, Y. / Williams, H. / Fedoseyenko, D. / Russell, W.K. / Kim, D. / Fleer, N. / Ealick, S.E. / Watanabe, C.M.
External linksBiochemistry / PubMed:26731610
MethodsX-ray diffraction
Resolution2.151 - 2.2 Å
Structure data

PDB-5hmb:
Crystal structure of S. sahachiroi AziG
Method: X-RAY DIFFRACTION / Resolution: 2.151 Å

PDB-5hmc:
Crystal structure of S. sahachiroi AziG complexed with 5-methyl naphthoic acid
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-5NE:
5-methylnaphthalene-1-carboxylic acid

Source
  • streptomyces sahachiroi (bacteria)
KeywordsHYDROLASE / azinomycin biosynthesis / polyketide synthase / thioesterase / naphthoate

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