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Structure paper

TitleEngineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
Journal, issue, pagesJ. Mol. Biol., Vol. 427, Page 2532-2547, Year 2015
Publish dateJan 4, 2015 (structure data deposition date)
AuthorsNocula-Lugowska, M. / Lugowski, M. / Salgia, R. / Kossiakoff, A.A.
External linksJ. Mol. Biol. / PubMed:26087144
MethodsX-ray diffraction
Resolution2 - 2.5 Å
Structure data

PDB-4xgz:
Crystal structure of human paxillin LD2 motif in complex with Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4xh2:
Crystal structure of human paxillin LD4 motif in complex with Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NO3:
NITRATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-LDA:
LAURYL DIMETHYLAMINE-N-OXIDE / LDAO, detergent*YM

ChemComp-ACE:
ACETYL GROUP

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsCELL ADHESION / synthetic antibody / paxillin / LD motif / immunoglobulin / Fab fragment / complex / focal adhesion

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