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Structure paper

TitleStructures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.
Journal, issue, pagesActa Crystallogr F Struct Biol Commun, Vol. 71, Page 609-614, Year 2015
Publish dateMay 9, 2012 (structure data deposition date)
AuthorsMoen, S.O. / Fairman, J.W. / Barnes, S.R. / Sullivan, A. / Nakazawa-Hewitt, S. / Van Voorhis, W.C. / Staker, B.L. / Lorimer, D.D. / Myler, P.J. / Edwards, T.E.
External linksActa Crystallogr F Struct Biol Commun / PubMed:25945716
MethodsX-ray diffraction
Resolution1.25 - 2.6 Å
Structure data

PDB-4f40:
X-ray crystal structure of Apo prostaglandin f synthase from Leishmania major Friedlin
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4fzi:
Crystal structure of prostaglandin F synthase from Trypanosoma cruzi
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4g5d:
X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4gie:
Crystal structure of prostaglandin F synthase from Trypanosoma cruzi bound to NADP
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

Chemicals

ChemComp-CIT:
CITRIC ACID

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-ACT:
ACETATE ION

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • leishmania major (eukaryote)
  • trypanosoma cruzi (eukaryote)
KeywordsOXIDOREDUCTASE / Structural Genomics / NIAID / National Institute of Allergy and Infectious Diseases / Seattle Structural Genomics Center for Infectious Disease / SSGCID / NADP / prostaglandin D2 / trypanosomiasis / eukaryotic pathogen / parasite / NADP+ / NADPH / rutin / bimatoprost / Chagas disease

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