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Structure paper

TitleStructural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page 18625-18630, Year 2014
Publish dateJun 17, 2014 (structure data deposition date)
AuthorsBhattacharya, A. / Alam, S.L. / Fricke, T. / Zadrozny, K. / Sedzicki, J. / Taylor, A.B. / Demeler, B. / Pornillos, O. / Ganser-Pornillos, B.K. / Diaz-Griffero, F. ...Bhattacharya, A. / Alam, S.L. / Fricke, T. / Zadrozny, K. / Sedzicki, J. / Taylor, A.B. / Demeler, B. / Pornillos, O. / Ganser-Pornillos, B.K. / Diaz-Griffero, F. / Ivanov, D.N. / Yeager, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:25518861
MethodsX-ray diffraction
Resolution1.996 - 2.6 Å
Structure data

PDB-4qnb:
Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.996 Å

PDB-4wym:
Structural basis of HIV-1 capsid recognition by CPSF6
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-1B0:
N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus type 1 (new york-5 isolate)
  • human immunodeficiency virus type 1 group m subtype b
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/INHIBITOR / capsid protein / disulfide crosslink / VIRAL PROTEIN / VIRAL PROTEIN-INHIBITOR complex / HEXAMER / ENGINEERED DISULFIDE BONDS / CPSF6 / viral restriction

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