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-Structure paper
Title | Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition. |
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Journal, issue, pages | Nat. Chem., Vol. 6, Page 1084-1090, Year 2014 |
Publish date | Mar 18, 2014 (structure data deposition date) |
Authors | Brem, J. / van Berkel, S.S. / Aik, W. / Rydzik, A.M. / Avison, M.B. / Pettinati, I. / Umland, K.D. / Kawamura, A. / Spencer, J. / Claridge, T.D. ...Brem, J. / van Berkel, S.S. / Aik, W. / Rydzik, A.M. / Avison, M.B. / Pettinati, I. / Umland, K.D. / Kawamura, A. / Spencer, J. / Claridge, T.D. / McDonough, M.A. / Schofield, C.J. |
External links | Nat. Chem. / PubMed:25411887 |
Methods | X-ray diffraction |
Resolution | 1.48 - 2 Å |
Structure data | PDB-4pvo: PDB-4pvt: PDB-4tyt: |
Chemicals | ChemComp-ZN: ChemComp-S3C: ChemComp-SVB: ChemComp-FMT: ChemComp-DMS: ChemComp-HOH: ChemComp-GOL: ChemComp-SO4: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / alpha-beta/beta-alpha fold / beta-lactamase / HYDROLASE-HYDROLASE INHIBITOR complex / alpha-beta/beta-alpha / HYDROLASE / antimicrobial resistance / metallo beta lactamase / inhibitor |