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Structure paper

TitleStructural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis.
Journal, issue, pagesNat Commun, Vol. 5, Page 5209-5209, Year 2014
Publish dateApr 14, 2014 (structure data deposition date)
AuthorsColes, C.H. / Mitakidis, N. / Zhang, P. / Elegheert, J. / Lu, W. / Stoker, A.W. / Nakagawa, T. / Craig, A.M. / Jones, E.Y. / Aricescu, A.R.
External linksNat Commun / PubMed:25385546
MethodsX-ray diffraction
Resolution2.5 - 3.15 Å
Structure data

PDB-4pbv:
Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4pbw:
Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-4pbx:
Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Synapse Cell signalling Cell surface receptor / Receptor protein tyrosine phosphatase (RPTP) / HYDROLASE

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