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TitlePotential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA.
Journal, issue, pagesAntimicrob. Agents Chemother., Vol. 58, Page 7083-7092, Year 2014
Publish dateNov 3, 2012 (structure data deposition date)
AuthorsStogios, P.J. / Kuhn, M.L. / Evdokimova, E. / Courvalin, P. / Anderson, W.F. / Savchenko, A.
External linksAntimicrob. Agents Chemother. / PubMed:25223995
MethodsX-ray diffraction
Resolution2.15 - 2.696 Å
Structure data

PDB-4hur:
Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with acetyl coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-4hus:
Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with virginiamycin M1
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

PDB-4myo:
Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus
Method: X-RAY DIFFRACTION / Resolution: 2.696 Å

Chemicals

ChemComp-ACO:
ACETYL COENZYME *A

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-VIR:
VIRGINIAMYCIN M1 / antibiotic*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-MG:
Unknown entry

Source
  • staphylococcus aureus (bacteria)
KeywordsTRANSFERASE / STRUCTURAL GENOMICS / ANTIBIOTIC RESISTANCE / CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES (CSGID) / NIAID / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES / XENOBIOTIC ACYLTRANSFERASE (XAT) FAMILY / HEXAPEPTIDE REPEAT ACYLTRANSFERASE / streptogramin group A antibiotic acetyltransferase / STREPTOGRAMIN GROUP A ANTIBIOTICS / STREPTOGRAMIN A / VIRGINIAMYCIN M1 / DALFOPRISTIN / ACETYL COENZYME A / COENZYME A / INTRACELLULAR / TRANSFERASE/ANTIBIOTIC / TRANSFERASE-ANTIBIOTIC complex / CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES / CSGID / LEFT-HANDED BETA HELIX DOMAIN / VIRGINIAMYCIN

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