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Structure paper

TitleMechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Journal, issue, pagesStructure, Vol. 22, Page 1252-1262, Year 2014
Publish dateApr 12, 2012 (structure data deposition date)
AuthorsLiu, W. / Zhan, C. / Cheng, H. / Kumar, P.R. / Bonanno, J.B. / Nathenson, S.G. / Almo, S.C.
External linksStructure / PubMed:25087510
MethodsX-ray diffraction
Resolution2.25 - 2.78 Å
Structure data

PDB-4en0:
Crystal structure of light
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-4j6g:
CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4kg8:
Crystal structure of light mutant
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-4kgg:
Crystal structure of light mutant2 and dcr3 complex
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

PDB-4kgq:
Crystal structure of a human light loop mutant in complex with dcr3
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsCYTOKINE / STRUCTURAL GENOMICS / PSI-BIOLOGY / NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM / NYSGRC / IMMUNITY / TNF SUPERFAMILY / HVEM / DCR3 / N-GLYCOSYLATION / MEMBRANE / SECRETED PROTEIN / ATOMS-TO-ANIMALS: THE IMMUNE FUNCTION NETWORK / IFN / Jelly-roll Fold / Bind TNF receptor HVEM and LTbR / LTbR / IMMUNE SYSTEM / LIGHT / TNF / TNFR / TNF14 / NEW HVEM / Protein Structure Initiative / Cytokine/Signaling Protein / Cytokine-Signaling Protein complex

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