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Structure paper

TitleStructure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Journal, issue, pagesNature, Vol. 512, Page 49-, Year 2014
Publish dateDec 5, 2013 (structure data deposition date)
AuthorsFischer, E.S. / Bohm, K. / Lydeard, J.R. / Yang, H. / Stadler, M.B. / Cavadini, S. / Nagel, J. / Serluca, F. / Acker, V. / Lingaraju, G.M. ...Fischer, E.S. / Bohm, K. / Lydeard, J.R. / Yang, H. / Stadler, M.B. / Cavadini, S. / Nagel, J. / Serluca, F. / Acker, V. / Lingaraju, G.M. / Tichkule, R.B. / Schebesta, M. / Forrester, W.C. / Schirle, M. / Hassiepen, U. / Ottl, J. / Hild, M. / Beckwith, R.E.J. / Harper, J.W. / Jenkins, J.L. / Thoma, N.H.
External linksNature / PubMed:25043012
MethodsX-ray diffraction
Resolution2.95 - 3.5 Å
Structure data

PDB-4ci1:
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide
Method: X-RAY DIFFRACTION / Resolution: 2.98 Å

PDB-4ci2:
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-4ci3:
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-EF2:
S-Thalidomide

ChemComp-HOH:
WATER

ChemComp-LVY:
S-Lenalidomide

ChemComp-Y70:
S-Pomalidomide

Source
  • homo sapiens (human)
  • gallus gallus (chicken)
KeywordsDNA BINDING PROTEIN/PROTEIN / DNA BINDING PROTEIN-PROTEIN COMPLEX / DNA BINDING PROTEIN-PROTEIN BINDING COMPLEX / UBIQUITIN / CONT / DNA BINDING PROTEIN/PROTEIN BINDING / DNA BINDING PROTEIN / DDB1 / CRBN / CULLIN / E3 LIGASE / THALIDOMIDE / CONTERGAN

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