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Structure paper

TitleA Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing
Journal, issue, pagesMol. Cell, Vol. 54, Page 737-, Year 2014
Publish dateMar 1, 2014 (structure data deposition date)
AuthorsChen, Y. / Boland, A. / Kuzuoglu-Ozturk, D. / Bawankar, P. / Loh, B. / Chang, C.T. / Weichenrieder, O. / Izaurralde, E.
External linksMol. Cell / PubMed:24768540
MethodsX-ray diffraction
Resolution1.65 - 2.05 Å
Structure data

PDB-4cru:
Complex of human CNOT9 and CNOT1 including one tryptophan
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-4crv:
Complex of human CNOT9 and CNOT1 including two tryptophans
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-4crw:
Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-TRP:
TRYPTOPHAN

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / TNRC6 BINDING / MIRISC / MRNA SILENCING / MRNA DEADENYLATION / ARGONAUTE / TRANSCRIPTION / CCR4-NOT / TRANSLATIONAL REPRESSION / MRNA DECAPPING / DEAD-BOX PROTEIN / P54 / RCK / HELICASE / EIF4A / TRANSLATION / MIRNA / P-BODIES

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