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TitleIdentification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M)
Journal, issue, pagesPlos One, Vol. 9, Page e85349-e85349, Year 2014
Publish dateApr 8, 2013 (structure data deposition date)
AuthorsXu, X. / Cai, Y. / Wei, Y. / Donate, F. / Juarez, J. / Parry, G. / Chen, L. / Meehan, E.J. / Ahn, R.W. / Ugolkov, A. ...Xu, X. / Cai, Y. / Wei, Y. / Donate, F. / Juarez, J. / Parry, G. / Chen, L. / Meehan, E.J. / Ahn, R.W. / Ugolkov, A. / Dubrovskyi, O. / O'halloran, T.V. / Huang, M. / Mazar, A.P.
External linksPlos One / PubMed:24465541
MethodsX-ray diffraction
Resolution1.6 - 4.5 Å
Structure data

PDB-4k23:
Structure of anti-uPAR Fab ATN-658
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4k24:
Structure of anti-uPAR Fab ATN-658 in complex with uPAR
Method: X-RAY DIFFRACTION / Resolution: 4.5 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM

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