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TitleN (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
Journal, issue, pagesPlos One, Vol. 8, Page e80755-e80755, Year 2013
Publish dateMay 27, 2013 (structure data deposition date)
AuthorsAmiable, C. / Pochet, S. / Padilla, A. / Labesse, G. / Kaminski, P.A.
External linksPlos One / PubMed:24260472
MethodsX-ray diffraction
Resolution1.69 - 2.24 Å
Structure data

PDB-4kxl:
Crystal structure of DNPH1 (RCL) with 6-CYCLOPENTYL-AMP
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-4kxm:
Crystal structure of DNPH1 (RCL) WITH N6-ISOPENTENYL-AMP
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-4kxn:
Crystal structure of DNPH1 (RCL) with kinetine riboside monophosphate
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-6C6:
N-cyclopentyladenosine 5'-(dihydrogen phosphate)

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-6IA:
N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE

ChemComp-6K6:
N-(furan-2-ylmethyl)adenosine 5'-(dihydrogen phosphate)

Source
  • rattus norvegicus (Norway rat)
KeywordsHYDROLASE / DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE N-GLYCOSIDASE

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