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Structure paper

TitleNew Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase.
Journal, issue, pagesBiochemistry, Vol. 52, Page 8036-8047, Year 2013
Publish dateApr 29, 2013 (structure data deposition date)
AuthorsCockrell, G.M. / Zheng, Y. / Guo, W. / Peterson, A.W. / Truong, J.K. / Kantrowitz, E.R.
External linksBiochemistry / PubMed:24138583
MethodsX-ray diffraction
Resolution2.1 - 2.4 Å
Structure data

PDB-4kgv:
The R state structure of E. coli ATCase with ATP bound
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4kgx:
The R state structure of E. coli ATCase with CTP bound
Method: X-RAY DIFFRACTION / Resolution: 2.202 Å

PDB-4kgz:
The R state structure of E. coli ATCase with UTP and Magnesium bound
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4kh0:
The R state structure of E. coli ATCase with ATP and Magnesium bound
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-4kh1:
The R state structure of E. coli ATCase with CTP,UTP, and Magnesium bound
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-PAL:
N-(PHOSPHONACETYL)-L-ASPARTIC ACID

ChemComp-ZN:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-CTP:
CYTIDINE-5'-TRIPHOSPHATE

ChemComp-UTP:
URIDINE 5'-TRIPHOSPHATE / UTP*YM

ChemComp-MG:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / pyrimidine nucleotide biosynthesis / feedback inhibition / competing pathway / product activation / allostery / competing pathway product activation

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