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TitleStructural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Journal, issue, pagesPlos Pathog., Vol. 9, Page e1003390-e1003390, Year 2013
Publish dateApr 9, 2013 (structure data deposition date)
AuthorsChen, E. / Paing, M.M. / Salinas, N. / Sim, B.K. / Tolia, N.H.
External linksPlos Pathog. / PubMed:23717209
MethodsX-ray diffraction
Resolution2.45 - 4.5 Å
Structure data

PDB-4k2u:
Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-4qex:
Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217
Method: X-RAY DIFFRACTION / Resolution: 4.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / DBL domain / Immunoglobulin domain / Antibody fragment / Cell attachment / Immunity / Receptor / Ligand / Extracellular / Duffy Binding Like (DBL) domain / Invasion / adhesion / PFEBA-175 / Antibody / Cell Surface / Extrecellular / Cell Adhesion

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