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Structure paper

TitleM2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 5881-5886, Year 2013
Publish dateJul 3, 2012 (structure data deposition date)
AuthorsMorgan, H.P. / O'Reilly, F.J. / Wear, M.A. / O'Neill, J.R. / Fothergill-Gilmore, L.A. / Hupp, T. / Walkinshaw, M.D.
External linksProc. Natl. Acad. Sci. USA / PubMed:23530218
MethodsX-ray diffraction
Resolution2.55 - 2.9 Å
Structure data

PDB-4fxf:
Structure of M2 pyruvate kinase in complex with phenylalanine
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-4fxj:
Structure of M2 pyruvate kinase in complex with phenylalanine
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-OXL:
OXALATE ION

ChemComp-K:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-PHE:
PHENYLALANINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / TIM Barrel / ATP binding / Phenylalanine binding

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