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Structure paper

TitleOne target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
Journal, issue, pagesJ. Mol. Biol., Vol. 425, Page 94-111, Year 2013
Publish dateJul 18, 2012 (structure data deposition date)
AuthorsBlech, M. / Peter, D. / Fischer, P. / Bauer, M.M. / Hafner, M. / Zeeb, M. / Nar, H.
External linksJ. Mol. Biol. / PubMed:23041424
MethodsX-ray diffraction
Resolution1.81 - 2.03 Å
Structure data

PDB-4g5z:
Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-4g6j:
Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-4g6k:
Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4g6m:
Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / immunoglobulin fold / antibody / immunoglobulin / interleukine-1beta binding / cytokine / blood system / immunglobulin fold / interleukin-1beta binding / interleukine-1beta

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