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Structure paper

TitleDiverse HIV viruses are targeted by a conformationally dynamic antiviral.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 411-416, Year 2012
Publish dateJan 25, 2012 (structure data deposition date)
AuthorsCaines, M.E. / Bichel, K. / Price, A.J. / McEwan, W.A. / Towers, G.J. / Willett, B.J. / Freund, S.M. / James, L.C.
External linksNat. Struct. Mol. Biol. / PubMed:22407016
MethodsX-ray diffraction
Resolution1.4 - 2.65 Å
Structure data

PDB-4dga:
TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4dgb:
TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex
Method: X-RAY DIFFRACTION / Resolution: 1.702 Å

PDB-4dgc:
TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-4dgd:
TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-4dge:
TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • macaca mulatta (Rhesus monkey)
  • human immunodeficiency virus 1
  • human immunodeficiency virus 2
  • tolypocladium inflatum (fungus)
KeywordsISOMERASE/VIRAL PROTEIN / anti-viral protein / ISOMERASE-VIRAL PROTEIN complex / ISOMERASE/IMMUNOSUPPRESSANT / ISOMERASE-IMMUNOSUPPRESSANT complex / ISOMERASE

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