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TitleStructural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2''-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 13094-13102, Year 2012
Publish dateFeb 20, 2012 (structure data deposition date)
AuthorsShi, K. / Berghuis, A.M.
External linksJ. Biol. Chem. / PubMed:22371504
MethodsX-ray diffraction
Resolution2.1 - 2.35 Å
Structure data

PDB-4dt8:
Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-4dt9:
Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Guanosine
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4dta:
Crystal Structure of F95M Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Adenosine
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-4dtb:
Crystal Structure of F95Y Aminoglycoside-2''-Phosphotransferase Type IVa in Complex with Guanosine
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ADN:
ADENOSINE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GMP:
GUANOSINE

Source
  • enterococcus casseliflavus (bacteria)
KeywordsTRANSFERASE / Aminoglycoside kinase

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