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Structure paper

TitleA series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency.
Journal, issue, pagesCell Death Differ., Vol. 19, Page 1187-1195, Year 2012
Publish dateAug 19, 2011 (structure data deposition date)
AuthorsChodorge, M. / Zuger, S. / Stirnimann, C. / Briand, C. / Jermutus, L. / Grutter, M.G. / Minter, R.R.
External linksCell Death Differ. / PubMed:22261618
MethodsX-ray diffraction
Resolution1.93 - 2.1 Å
Structure data

PDB-3thm:
Crystal structure of Fas receptor extracellular domain in complex with Fab EP6b_B01
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3tje:
Crystal structure of Fas receptor extracellular domain in complex with Fab E09
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-CD:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Agonistic antibody / Fab fragment / antibody-receptor complex / tumor necrosis factor receptor / cysteine-rich domain / Fas

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