タイトル | Catalysis-based inhibitors of the calcium signaling function of CD38. |
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ジャーナル・号・ページ | Biochemistry, Vol. 51, Page 555-564, Year 2012 |
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掲載日 | 2011年4月26日 (構造データの登録日) |
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著者 | Kwong, A.K. / Chen, Z. / Zhang, H. / Leung, F.P. / Lam, C.M. / Ting, K.Y. / Zhang, L. / Hao, Q. / Zhang, L.H. / Lee, H.C. |
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リンク | Biochemistry / PubMed:22142305 |
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手法 | X線回折 |
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解像度 | 1.65 - 2.1 Å |
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構造データ | PDB-3rok: Crystal structure of human CD38 in complex with compound CZ-27 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-3rom: Crystal structure of human CD38 in complex with compound CZ-48 手法: X-RAY DIFFRACTION / 解像度: 2.04 Å PDB-3rop: Crystal structure of human CD38 in complex with compound CZ-50b 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-3roq: Crystal structure of human CD38 in complex with compound CZ-46 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-27C: 5-O-[(S)-butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-alpha-D-arabinofuranose
ChemComp-48Z: 2-deoxy-2-fluoro-5-O-thiophosphono-alpha-D-arabinofuranose
ChemComp-50A: 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-ribofuranose
ChemComp-46Z: (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / CD38 (CD38) / ADP-ribosyl cyclase (NAD(P)+ヌクレオシダーゼ) / cyclic ADP-ribose (環状アデノシン二リン酸リボース) / Calcium signaling (カルシウムシグナリング) / inhibitory compound / covalent intermediate / CZ-27 / HYDROLASE-HYDROLASE INHIBITOR complex / X-crystallography / CZ-48 / CZ-50b / CZ-46 |
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