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Structure paper

TitleThe rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 35096-35103, Year 2011
Publish dateAug 23, 2011 (structure data deposition date)
AuthorsPark, H. / Lee, J.H. / Gouin, E. / Cossart, P. / Izard, T.
External linksJ. Biol. Chem. / PubMed:21841197
MethodsX-ray diffraction
Resolution1.99 - 2.76 Å
Structure data

PDB-3tj5:
human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-N; residues 412-434) from Rickettsia rickettsii
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-3tj6:
human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii
Method: X-RAY DIFFRACTION / Resolution: 2.76 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • rickettsia rickettsii str. iowa (bacteria)
  • rickettsia rickettsii (bacteria)
Keywordsprotein binding/toxin / cytoskeleton / epidemic typhus / sca4 / spotted fever / ALPHA-HELIX BUNDLE DOMAIN / PROTEIN-PROTEIN INTERACTIONS / CELL ADHESION / CYTOSOL / FOCAL ADHESION / protein binding-toxin complex

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