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Structure paper

TitleStructural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 17, Page 165-172, Year 2010
Publish dateDec 14, 2009 (structure data deposition date)
AuthorsLeung, D.W. / Prins, K.C. / Borek, D.M. / Farahbakhsh, M. / Tufariello, J.M. / Ramanan, P. / Nix, J.C. / Helgeson, L.A. / Otwinowski, Z. / Honzatko, R.B. ...Leung, D.W. / Prins, K.C. / Borek, D.M. / Farahbakhsh, M. / Tufariello, J.M. / Ramanan, P. / Nix, J.C. / Helgeson, L.A. / Otwinowski, Z. / Honzatko, R.B. / Basler, C.F. / Amarasinghe, G.K.
External linksNat. Struct. Mol. Biol. / PubMed:20081868
MethodsX-ray diffraction
Resolution1.95 - 2.4 Å
Structure data

PDB-3l25:
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3l26:
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3l27:
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain R312A mutant
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-3l28:
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-K:
Unknown entry

ChemComp-SO4:
SULFATE ION

Source
  • zaire ebolavirus
KeywordsRNA BINDING PROTEIN/RNA / RNA BINDING DOMAIN / COILED COIL / INTERFERON ANTIVIRAL SYSTEM EVASION / RNA REPLICATION / RNA BINDING PROTEIN / TRANSCRIPTION / Host cytoplasm / RNA-binding / Virion / RNA BINDING PROTEIN-RNA complex / INTERFERON ANTIVIRAL EVASION / RNA-BINDING PROTEIN

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