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Structure paper

TitleStructure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 2174-2183, Year 2010
Publish dateSep 23, 2009 (structure data deposition date)
AuthorsPhan, J. / Li, Z. / Kasprzak, A. / Li, B. / Sebti, S. / Guida, W. / Schonbrunn, E. / Chen, J.
External linksJ. Biol. Chem. / PubMed:19910468
MethodsX-ray diffraction
Resolution1.74 - 2.1 Å
Structure data

PDB-3jzo:
Human MDMX liganded with a 12mer peptide (pDI)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3jzp:
Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-3jzq:
Human MDMX liganded with a 12mer peptide inhibitor (pDIQ)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3jzr:
Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3jzs:
Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ)
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / P53-BINDING PROTEIN MDM4 / DOUBLE MINUTE 4 PROTEIN / Alternative splicing / Metal-binding / Nucleus / Polymorphism / Zinc / Zinc-finger / LIGASE / P53-BINDING PROTEIN MDM2 / ONCOPROTEIN MDM2 / DOUBLE MINUTE 2 PROTEIN / HDM2 / Cytoplasm / Host-virus interaction / Phosphoprotein / Proto-oncogene / Ubl conjugation / Ubl conjugation pathway

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