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Structure paper

TitleStructural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 16, Page 698-, Year 2009
Publish dateApr 14, 2009 (structure data deposition date)
AuthorsBishop, B. / Aricescu, A.R. / Harlos, K. / O'Callaghan, C.A. / Jones, E.Y. / Siebold, C.
External linksNat. Struct. Mol. Biol. / PubMed:19561611
MethodsX-ray diffraction
Resolution1.85 - 3.2 Å
Structure data

PDB-2wfq:
Crystal structure of the N-terminal signalling domain of human Dhh without calcium
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2wfr:
Crystal structure of the N-terminal signalling domain of human Dhh with calcium
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2wft:
Crystal structure of the human HIP ectodomain
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2wfx:
Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-2wg3:
Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2wg4:
Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / LIPOPROTEIN / DEVELOPMENT / CELL MEMBRANE / AUTOCATALYTIC CLEAVAGE / DISEASE MUTATION / HEDGEHOG SIGNALLING / PROTEASE / MEMBRANE / SECRETED / PALMITATE / HYDROLASE / SIGNAL TRANSDUCTION / DEVELOPMENTAL PROTEIN / CYTOPLASM / DISULFIDE BOND / EGF-LIKE DOMAIN / ALTERNATIVE SPLICING / POLYMORPHISM / GLYCOPROTEIN / HEDGEHOG SIGNALING

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