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TitleA cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 105, Page 20251-20256, Year 2008
Publish dateSep 26, 2008 (structure data deposition date)
AuthorsWilkinson, T. / Turner, R. / Podichetty, S. / Finch, D. / McCourt, M. / Loning, S. / Jermutus, L.
External linksProc. Natl. Acad. Sci. Usa / PubMed:19073914
MethodsX-ray diffraction
Resolution1.75 - 3.1 Å
Structure data

PDB-3eo0:
Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-3eo1:
Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Cytokine neutralizing antibody / FAB fragment / IMMUNE SYSTEM/CYTOKINE / Antibody-cytokine complex / Growth factor / Cardiomyopathy / Cleavage on pair of basic residues / Glycoprotein / Mitogen / Polymorphism / Secreted / IMMUNE SYSTEM-CYTOKINE COMPLEX

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