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-Structure paper
タイトル | Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer. |
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ジャーナル・号・ページ | J Mol Biol, Vol. 368, Issue 4, Page 1011-1023, Year 2007 |
掲載日 | 2007年5月11日 |
著者 | Ljiljana Sjekloća / Regina Pudas / Björn Sjöblom / Peter Konarev / Oliviero Carugo / Vladimir Rybin / Tiila-Riikka Kiema / Dmitri Svergun / Jari Ylänne / Kristina Djinović Carugo / |
PubMed 要旨 | Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ...Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions. |
リンク | J Mol Biol / PubMed:17379241 |
手法 | SAS (X-ray synchrotron) / X線回折 |
解像度 | 2.05 Å |
構造データ | SASDAC4: PDB-2nqc: |
化合物 | ChemComp-NI: ChemComp-IMD: ChemComp-GOL: ChemComp-HOH: |
由来 |
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キーワード | IMMUNE SYSTEM / FILAMIN / IMMUNOGLOBULIN / METAL BINDING |