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Structure paper

TitleThe Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 104, Page 5336-, Year 2007
Publish dateJul 13, 2006 (structure data deposition date)
AuthorsBolam, D.N. / Roberts, S.M. / Proctor, M.R. / Turkenburg, J.P. / Dodson, E.J. / Martinez-Fleites, C. / Yang, M. / Davis, B.G. / Davies, G.J. / Gilbert, H.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:17376874
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-2iya:
The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2iyf:
The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-ZIO:
(3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE / antibiotic*YM

ChemComp-HOH:
WATER

ChemComp-ERY:
ERYTHROMYCIN A / antibiotic*YM

ChemComp-MG:
Unknown entry

Source
  • streptomyces antibioticus (bacteria)
KeywordsTRANSFERASE / CARBOHYDRATE / GLYCOSYLATION / GLYCOSYLTRANSFERASE / ENZYME / MACROLIDE / ANTIBIOTIC RESISTANCE

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