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Structure paper

TitleStructure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Journal, issue, pagesNat. Chem. Biol., Vol. 3, Page 101-107, Year 2007
Publish dateNov 6, 2006 (structure data deposition date)
AuthorsLieberman, R.L. / Wustman, B.A. / Huertas, P. / Powe, A.C. / Pine, C.W. / Khanna, R. / Schlossmacher, M.G. / Ringe, D. / Petsko, G.A.
External linksNat. Chem. Biol. / PubMed:17187079
MethodsX-ray diffraction
Resolution1.79 - 2.3 Å
Structure data

PDB-2nsx:
Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-2nt0:
Acid-beta-glucosidase low pH, glycerol bound
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-2nt1:
Structure of acid-beta-glucosidase at neutral pH
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-IFM:
5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / TIM-barrel glycosidase Cerezyme hydrolysis / cerezyme / glucocerebrosidase / glucosylceramide / hydrolysis / gaucher disease / acid-beta-glucosidase

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