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Structure paper

TitleStructures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Journal, issue, pagesNature, Vol. 443, Page 870-874, Year 2006
Publish dateFeb 21, 2006 (structure data deposition date)
AuthorsShen, Y. / Joachimiak, A. / Rosner, M.R. / Tang, W.J.
External linksNature / PubMed:17051221
MethodsX-ray diffraction
Resolution2.1 - 2.6 Å
Structure data

PDB-2g47:
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2g48:
crystal structure of human insulin-degrading enzyme in complex with amylin
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2g49:
Crystal structure of human insulin-degrading enzyme in complex with glucagon
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2g54:
Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B chain
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2g56:
crystal structure of human insulin-degrading enzyme in complex with insulin B chain
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE / protein-peptide complex

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