タイトル | The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. |
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ジャーナル・号・ページ | Nature, Vol. 443, Page 45-49, Year 2006 |
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掲載日 | 2006年7月25日 (構造データの登録日) |
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著者 | Russell, R.J. / Haire, L.F. / Stevens, D.J. / Collins, P.J. / Lin, Y.P. / Blackburn, G.M. / Hay, A.J. / Gamblin, S.J. / Skehel, J.J. |
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リンク | Nature / PubMed:16915235 |
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手法 | X線回折 |
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解像度 | 2.2 - 3.5 Å |
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構造データ | PDB-2ht5: N8 Neuraminidase 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2ht7: N8 neuraminidase in open complex with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-2ht8: N8 neuraminidase in complex with oseltamivir 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-2htq: N8 neuraminidase in complex with zanamivir 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2htr: N8 neuraminidase in complex with DANA 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2htu: N8 neuraminidase in complex with peramivir 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2htv: N4 neuraminidase 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2htw: N4 neuraminidase in complex with DANA 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å PDB-2hty: N1 neuraminidase 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2hu0: N1 neuraminidase in complex with oseltamivir 1 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å PDB-2hu4: N1 neuraminidase in complex with oseltamivir 2 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-G39: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid / オセルタミビルカルボキシラ-ト / 薬剤, 抗ウイルス剤*YM
ChemComp-BCZ: 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID / ペラミビル / 抗ウイルス剤, 阻害剤*YM
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由来 | - influenza a virus (A型インフルエンザウイルス)
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キーワード | HYDROLASE / N8 / neuraminidase / oseltamivir / zanamivir / DANA / peramivir / N4 / N1 |
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