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Structure paper

TitleStructure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 103, Page 11898-11903, Year 2006
Publish dateJun 14, 2006 (structure data deposition date)
AuthorsMidtgaard, S.F. / Assenholt, J. / Jonstrup, A.T. / Van, L.B. / Jensen, T.H. / Brodersen, D.E.
External linksProc. Natl. Acad. Sci. Usa / PubMed:16882719
MethodsX-ray diffraction
Resolution2.1 - 2.7 Å
Structure data

PDB-2hbj:
Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2hbk:
Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain; Protein in complex with Mn
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2hbl:
Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain; Protein in complex with Mn, Zn, and AMP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2hbm:
Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain; Protein in complex with Mn, Zn, and UMP
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsHYDROLASE / GENE REGULATION / exosome / RNA metabolism / RNA surveillance / RNA processing

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