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-Structure paper
| タイトル | ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane. |
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| ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 12, Issue 11, Page 1015-1016, Year 2005 |
| 掲載日 | 2006年5月31日 |
著者 | Michael Blau / Srinivas Mullapudi / Thomas Becker / Johanna Dudek / Richard Zimmermann / Pawel A Penczek / Roland Beckmann / ![]() |
| PubMed 要旨 | Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). ...Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). Recently, a new RAMP, ERj1p, has been identified that recruits BiP to ribosomes and regulates translational activity. Here we present the cryo-EM structure of a ribosome-ERj1p complex, revealing how ERj1p coordinates the ribosome at the membrane and how allosteric effects may mediate ERj1p's regulatory activity. |
リンク | Nat Struct Mol Biol / PubMed:16244660 |
| 手法 | EM (単粒子) |
| 解像度 | 20.0 - 23.0 Å |
| 構造データ | ![]() EMDB-1168: ![]() EMDB-1169: |
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