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Structure paper

TitleExotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Journal, issue, pagesNature, Vol. 436, Page 979-984, Year 2005
Publish dateMay 10, 2005 (structure data deposition date)
AuthorsJoergensen, R. / Merrill, A.R. / Yates, S.P. / Marquez, V.E. / Schwan, A.L. / Boesen, T. / Andersen, G.R.
External linksNature / PubMed:16107839
MethodsX-ray diffraction
Resolution2.8 - 3.07 Å
Structure data

PDB-1zm2:
Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA
Method: X-RAY DIFFRACTION / Resolution: 3.07 Å

PDB-1zm3:
Structure of the apo eEF2-ETA complex
Method: X-RAY DIFFRACTION / Resolution: 3.07 Å

PDB-1zm4:
Structure of the eEF2-ETA-bTAD complex
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-1zm9:
Structure of eEF2-ETA in complex with PJ34
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-APR:
ADENOSINE-5-DIPHOSPHORIBOSE

ChemComp-TAD:
BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE

ChemComp-P34:
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE

Source
  • pseudomonas aeruginosa (bacteria)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsBIOSYNTHETIC PROTEIN/TRANSFERASE / elongation factor / toxin / ADP-ribosylation / BIOSYNTHETIC PROTEIN-TRANSFERASE COMPLEX

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