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TitleCytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.
Journal, issue, pagesNat Neurosci, Vol. 8, Issue 3, Page 279-287, Year 2005
Publish dateFeb 20, 2005
AuthorsScott Pegan / Christine Arrabit / Wei Zhou / Witek Kwiatkowski / Anthony Collins / Paul A Slesinger / Senyon Choe /
PubMed AbstractN- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. ...N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two new crystal structures of the cytoplasmic domains of Kir2.1 (Kir2.1(L)) and the G protein-sensitive Kir3.1 (Kir3.1(S)) channels in the absence of PIP(2) show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central pore (G-loop). Significant flexibility of the pore-facing G-loop of Kir2.1(L) and Kir3.1(S) suggests a possible role as a diffusion barrier between cytoplasmic and transmembrane pores. Consistent with this, mutations of the G-loop disrupted gating or inward rectification. Structural comparison shows a di-aspartate cluster on the distal end of the cytoplasmic pore of Kir2.1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification.
External linksNat Neurosci / PubMed:15723059
MethodsX-ray diffraction
Resolution2.09 - 2.41 Å
Structure data

PDB-1u4e:
Crystal Structure of Cytoplasmic Domains of GIRK1 channel
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-1u4f:
Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • mus musculus (house mouse)
KeywordsMETAL TRANSPORT / ALLERGEN / cytoplasmic domain / Kir2.1 / IRK1 / inwardly rectifying K channel / rectification

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