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TitleElectron cryo-microscopy structure of a human TRPM4 channel.
Journal, issue, pagesNature, Vol. 552, Issue 7684, Page 200-204, Year 2017
Publish dateDec 14, 2017
AuthorsPaige A Winkler / Yihe Huang / Weinan Sun / Juan Du / Wei Lü /
PubMed AbstractCa-activated, non-selective (CAN) ion channels sense increases of the intracellular Ca concentration, producing a flux of Na and/or K ions that depolarizes the cell, thus modulating cellular Ca entry. ...Ca-activated, non-selective (CAN) ion channels sense increases of the intracellular Ca concentration, producing a flux of Na and/or K ions that depolarizes the cell, thus modulating cellular Ca entry. CAN channels are involved in cellular responses such as neuronal bursting activity and cardiac rhythm. Here we report the electron cryo-microscopy structure of the most widespread CAN channel, human TRPM4, bound to the agonist Ca and the modulator decavanadate. Four cytosolic C-terminal domains form an umbrella-like structure with a coiled-coil domain for the 'pole' and four helical 'ribs' spanning the N-terminal TRPM homology regions (MHRs), thus holding four subunits in a crown-like architecture. We observed two decavanadate-binding sites, one in the C-terminal domain and another in the intersubunit MHR interface. A glutamine in the selectivity filter may be an important determinant of monovalent selectivity. Our structure provides new insights into the function and pharmacology of both the CAN and the TRPM families.
External linksNature / PubMed:29211723
MethodsEM (single particle)
Resolution3.8 Å
Structure data

EMDB-8871, PDB-5wp6:
Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate
Method: EM (single particle) / Resolution: 3.8 Å

Chemicals

ChemComp-DVT:
DECAVANADATE

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Ion channel

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