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Structure paper

TitleMolecular basis of human CD22 function and therapeutic targeting.
Journal, issue, pagesNat Commun, Vol. 8, Issue 1, Page 764-764, Year 2017
Publish dateOct 2, 2017
AuthorsJune Ereño-Orbea / Taylor Sicard / Hong Cui / Mohammad T Mazhab-Jafari / Samir Benlekbir / Alba Guarné / John L Rubinstein / Jean-Philippe Julien
External linksPubMed:28970495 / Publisher's page
MethodsEM (single particle) / X-ray diffraction / SAS (X-ray synchrotron)
Resolution2.014 - 30 A
Structure data

EMDB-8704:
Negative stain electron microscopy map of human CD22 extracellular domain

EMDB-8705:
Negative stain electron microscopy map of human CD22 extracellular domain in complex with epratuzumab Fab

PDB-5vkj:
Crystal structure of human CD22 Ig domains 1-3

PDB-5vkk:
Crystal structure of Fab fragment of anti-CD22 Epratuzumab

PDB-5vkm:
Crystal structure of human CD22 Ig domains 1-3 in complex with alpha 2-6 sialyllactose

PDB-5vl3:
CD22 d1-d3 in complex with therapeutic Fab Epratuzumab

SASDC76:
Extracellular domain of human B-lymphocyte cell receptor CD22

SASDC86:
Extracellular domain of human B-lymphocyte cell receptor CD22 in complex with alpha 2,6 sialyllactose

Chemicals

ChemComp-NAG:
N-ACETYL-D-GLUCOSAMINE

ChemComp-BMA:
BETA-D-MANNOSE

ChemComp-MAN:
ALPHA-D-MANNOSE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GAL:
BETA-D-GALACTOSE

ChemComp-SIA:
O-SIALIC ACID

SourceHomo sapiens / human
Mus musculus / mammal / ハツカネズミ, はつかねずみ /
KeywordsIMMUNE SYSTEM / Siglec / Sialic acid / carbohydrate binding protein / therapeutic antibody / B cell / Fab

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About EMN Papers

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Oct 4, 2017. Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

  • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
  • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
  • Richard Henderson (MRC Laboratory of Molecular Biology, Cambridge, UK) was determined the first biomolecule structure by EM. The first EM entry in PDB, PDB-1brd is determinedby him.

External links: The 2017 Nobel Prize in Chemistry - Press Release

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Jul 12, 2017. Major update of PDB

Major update of PDB

  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary. This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated. See below links for details.
  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software). Now, EM Navigator and Yorodumi are based on the updated data.

External links: wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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Jun 16, 2017. Omokage search with filter

Omokage search with filter

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Sep 15, 2016. EM Navigator & Yorodumi renewed

EM Navigator & Yorodumi renewed

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Related info.: Changes in new EM Navigator and Yorodumi / EM Navigator (legacy version) / Yorodumi (legacy version)

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Aug 31, 2016. New EM Navigator & Yorodumi

New EM Navigator & Yorodumi

  • In 15th Sep 2016, the development versions of EM Navigator and Yorodumi will replace the official versions.
  • Current version will continue as 'legacy version' for some time.

Related info.: Changes in new EM Navigator and Yorodumi / EM Navigator / Yorodumi / EM Navigator (legacy version) / Yorodumi (legacy version)

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EMN Papers

Database of articles cited by 3DEM data entries

  • Database of articles cited by 3DEM data entries in EMDB and PDB
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