5GHW

Crystal structure of broad neutralizing antibody 10E8 with long epitope bound

Summary for 5GHW

Entry DOI	10.2210/pdb5ghw/pdb
Descriptor	FAB 10E8 HEAVY CHAIN, FAB 10E8 LIGHT CHAIN, Endogenous retrovirus group K member 8 Env polyprotein, ... (5 entities in total)
Functional Keywords	broad neutralizing antibody, recombinant fab, epitope, immune system, hiv-1, viral membrane
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	54089.79
Authors	Caaveiro, J.M.M.,Rujas, E.,Morante, K.,Nieva, J.L.,Tsumoto, K. (deposition date: 2016-06-21, release date: 2016-11-23, Last modification date: 2023-11-08)
Primary citation	Rujas, E.,Caaveiro, J.M.,Partida-Hanon, A.,Gulzar, N.,Morante, K.,Apellaniz, B.,Garcia-Porras, M.,Bruix, M.,Tsumoto, K.,Scott, J.K.,Jimenez, M.A.,Nieva, J.L. Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface Sci Rep, 6:38177-38177, 2016 Cited by PubMed: 27905530 DOI: 10.1038/srep38177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation