5B8C

High resolution structure of the human PD-1 in complex with pembrolizumab Fv

Summary for 5B8C

Entry DOI	10.2210/pdb5b8c/pdb
Descriptor	Pembrolizumab light chain variable region (PemVL), Pembrolizumab heavy chain variable region (PemVH), Programmed cell death protein 1, ... (4 entities in total)
Functional Keywords	antibody, immune system
Biological source	Homo sapiens More
Cellular location	Membrane; Single-pass type I membrane protein: Q15116
Total number of polymer chains	12
Total formula weight	168002.49
Authors	Horita, S.,Shimamura, T.,Iwata, S.,Nomura, N. (deposition date: 2016-06-14, release date: 2016-10-26, Last modification date: 2023-11-08)
Primary citation	Horita, S.,Nomura, Y.,Sato, Y.,Shimamura, T.,Iwata, S.,Nomura, N. High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1 Sci Rep, 6:35297-35297, 2016 Cited by PubMed: 27734966 DOI: 10.1038/srep35297 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.146 Å)

Structure validation