PDB: 9 resultsInfo pagesStatus searchChemie searchBIRD

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8VHG	Structure of the BMAL1/HIF2A heterodimer in Complex with DNA Descriptor: Basic helix-loop-helix ARNT-like protein 1, Endothelial PAS domain-containing protein 1, Forward strand DNA containing HRE motif, ... Authors: Li, T, Tsai, K.L. Deposit date: 2024-01-01 Release date: 2025-02-12 Last modified: 2025-05-07 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. Nature, 2025
8RW6	Human Brain and muscle ARNT-like 1 (BMAL1_HUMAN) PAS-B domain Descriptor: Basic helix-loop-helix ARNT-like protein 1 Authors: Pu, H, Rastinejad, F. Deposit date: 2024-02-02 Release date: 2025-02-05 Last modified: 2025-05-07 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Pharmacological targeting of BMAL1 modulates circadian and immune pathways. Nat.Chem.Biol., 21, 2025
8RW8	Brain and muscle ARNT-like 1 (BMAL1) PAS-B domain in-complex with core circadian modulator (CCM) Descriptor: (2~{R})-3-[(4-ethyl-1-benzofuran-7-yl)oxy]-2-fluoranyl-propan-1-ol, (2~{S})-3-[(4-ethyl-1-benzofuran-7-yl)oxy]-2-fluoranyl-propan-1-ol, Basic helix-loop-helix ARNT-like protein 1 Authors: Pu, H, Rastinejad, F. Deposit date: 2024-02-02 Release date: 2025-02-05 Last modified: 2025-05-07 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Pharmacological targeting of BMAL1 modulates circadian and immune pathways. Nat.Chem.Biol., 21, 2025
4F3L	Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex Descriptor: BMAL1b, Circadian locomoter output cycles protein kaput Authors: Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J. Deposit date: 2012-05-09 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.268 Å) Cite: Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science, 337, 2012
4H10	Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic Helix-Loop-Helix domains with E-box DNA Descriptor: Aryl hydrocarbon receptor nuclear translocator-like protein 1, Circadian locomoter output cycles protein kaput, E-box DNA antisense strand, ... Authors: Wang, Z, Su, X.-D. Deposit date: 2012-09-10 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.402 Å) Cite: Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA. Cell Res., 23, 2013
8OSL	Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... Authors: Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSK	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... Authors: Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSJ	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... Authors: Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
2KDK	Structure of human circadian clock protein BMAL2 C-terminal PAS domain Descriptor: Aryl hydrocarbon receptor nuclear translocator-like protein 2 Authors: Wasielewski, E, Correia, C, Prendergast, F.G, Mer, G. Deposit date: 2009-01-10 Release date: 2011-04-13 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure of human circadian clock protein BMAL2 C-terminal PAS domain To be Published