登録情報 データベース : PDB / ID : 6i7q 構造の表示 ダウンロードとリンクタイトル Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form 要素Elongin-B Elongin-C Endothelial PAS domain-containing protein 1 von Hippel-Lindau disease tumor suppressor 詳細キーワード GENE REGULATION (遺伝子発現の調節) / E3 UBIQUITIN LIGASE (ユビキチンリガーゼ) / von Hippel Lindau / Prolyl hydroxylation / HIF / TUMOR SUPPRESSOR (がん抑制遺伝子) / CANCER (悪性腫瘍) / PROTEOSOMAL DEGRADATION / UBIQUITIN (ユビキチン)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA Polymerase II Pre-transcription Events / myoblast fate commitment / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Cellular response to hypoxia / regulation of protein neddylation / Transcriptional regulation of pluripotent stem cells / PTK6 Expression / regulation of cellular response to hypoxia ... RNA Polymerase II Pre-transcription Events / myoblast fate commitment / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Cellular response to hypoxia / regulation of protein neddylation / Transcriptional regulation of pluripotent stem cells / PTK6 Expression / regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / norepinephrine metabolic process / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / surfactant homeostasis / epithelial cell maturation / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Regulation of gene expression by Hypoxia-inducible Factor / Cul2-RING ubiquitin ligase complex / intracellular non-membrane-bounded organelle / SUMOylation of ubiquitinylation proteins / negative regulation of transcription elongation by RNA polymerase II / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / ubiquitin-like ligase-substrate adaptor activity / embryonic placenta development / Tat-mediated elongation of the HIV-1 transcript / blood vessel remodeling / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / negative regulation of signal transduction / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / 視覚 / Pexophagy / regulation of heart rate / mitochondrion organization / 赤血球形成 / negative regulation of autophagy / transcription corepressor binding / Evasion by RSV of host interferon responses / transcription elongation by RNA polymerase II / transcription initiation at RNA polymerase II promoter / positive regulation of cell differentiation / TP53 Regulates Transcription of DNA Repair Genes / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Vif-mediated degradation of APOBEC3G / lung development / mRNA transcription by RNA polymerase II / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / cell morphogenesis / Inactivation of CSF3 (G-CSF) signaling / transcription coactivator binding / Regulation of expression of SLITs and ROBOs / multicellular organismal-level iron ion homeostasis / ubiquitin-protein transferase activity / transcription corepressor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / Neddylation / positive regulation of cold-induced thermogenesis / Replication of the SARS-CoV-2 genome / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / 遺伝子発現の調節 / DNA-binding transcription activator activity, RNA polymerase II-specific / proteasome-mediated ubiquitin-dependent protein catabolic process / protein-containing complex assembly / DNA-binding transcription factor binding / 血管新生 / response to oxidative stress / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / amyloid fibril formation / molecular adaptor activity / protein stabilization / response to hypoxia / DNA-binding transcription factor activity, RNA polymerase II-specific / protein ubiquitination / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein heterodimerization activity / negative regulation of cell population proliferation / negative regulation of gene expression / ubiquitin protein ligase binding / クロマチン / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II 類似検索 - 分子機能 von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / Elongin C; Chain C, domain 1 / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / 低酸素誘導因子 / Nuclear translocator / von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain ... von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / Elongin C; Chain C, domain 1 / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / 低酸素誘導因子 / Nuclear translocator / von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / VHL superfamily / von Hippel-Lindau disease tumour suppressor, alpha domain superfamily / von Hippel-Lindau disease tumour suppressor, beta domain superfamily / VHL beta domain / VHL box domain / Elongin B / Elongin-C / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / PAS domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / PAS fold / PAS fold / SKP1/BTB/POZ domain superfamily / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Ubiquitin-like (UB roll) / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / ユビキチン様タンパク質 / Ubiquitin-like domain superfamily / Roll / Immunoglobulin-like / サンドイッチ / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 von Hippel-Lindau disease tumor suppressor / Elongin-B / Elongin-C / Endothelial PAS domain-containing protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)Bos taurus (ウシ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.798 Å 詳細データ登録者 Chowdhury, R. / Aguilera, L.S. / Schofield, C.J. 引用 残り1件を表示 表示を減らす#1: ジャーナル : Nature / 年 : 2002タイトル : Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
著者 :
Hon, W.C. / Wilson, M.I. / Harlos, K. / Claridge, T.D. / Schofield, C.J. / Pugh, C.W. / Maxwell, P.H. / Ratcliffe, P.J. / Stuart, D.I. / Jones, E.Y. 履歴 登録 2018年11月17日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年11月27日 Provider : repository / タイプ : Initial release改定 1.1 2021年1月20日 Group : Database references / Derived calculations ... Database references / Derived calculations / Refinement description / Source and taxonomy / Structure summary カテゴリ : entity / entity_name_com ... entity / entity_name_com / pdbx_entity_src_syn / pdbx_struct_mod_residue / refine / struct_ref / struct_ref_seq / struct_ref_seq_dif Item : _entity.pdbx_description / _pdbx_entity_src_syn.organism_common_name ... _entity.pdbx_description / _pdbx_entity_src_syn.organism_common_name / _refine.solvent_model_details / _struct_ref.db_code / _struct_ref.db_name / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.pdbx_db_accession 改定 1.2 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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