Entry | Database: PDB / ID: 5ld8 |
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Title | GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA |
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Components | 3-oxoacyl-[acyl-carrier-protein] synthase 1 |
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Keywords | TRANSFERASE / INHIBITOR / COMPLEX / KASA / MYCOBACTERIUM TUBERCULOSIS |
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Function / homology | Function and homology information
meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I / fatty acid elongation, saturated fatty acid / fatty acid elongation / 3-oxoacyl-[acyl-carrier-protein] synthase activity / peptidoglycan-based cell wall / fatty acid biosynthetic process / identical protein binding / plasma membrane / cytosolSimilarity search - Function Beta-ketoacyl synthase / Thiolase/Chalcone synthase / Peroxisomal Thiolase; Chain A, domain 1 / Ketosynthase family 3 (KS3) domain profile. / Beta-ketoacyl synthase / Polyketide synthase, beta-ketoacyl synthase domain / Beta-ketoacyl synthase, N-terminal / Beta-ketoacyl synthase, C-terminal / Beta-ketoacyl synthase, N-terminal domain / Beta-ketoacyl synthase, C-terminal domain ...Beta-ketoacyl synthase / Thiolase/Chalcone synthase / Peroxisomal Thiolase; Chain A, domain 1 / Ketosynthase family 3 (KS3) domain profile. / Beta-ketoacyl synthase / Polyketide synthase, beta-ketoacyl synthase domain / Beta-ketoacyl synthase, N-terminal / Beta-ketoacyl synthase, C-terminal / Beta-ketoacyl synthase, N-terminal domain / Beta-ketoacyl synthase, C-terminal domain / Thiolase-like / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) ![](data/taxo/wicon/TB_Culture.jpg) Mycobacterium tuberculosis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.13 Å |
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Authors | Chung, C.W. / Neu, M. |
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Citation | Journal: Nat Commun / Year: 2016 Title: Identification of KasA as the cellular target of an anti-tubercular scaffold. Authors: Abrahams, K.A. / Chung, C.W. / Ghidelli-Disse, S. / Rullas, J. / Rebollo-Lopez, M.J. / Gurcha, S.S. / Cox, J.A. / Mendoza, A. / Jimenez-Navarro, E. / Martinez-Martinez, M.S. / Neu, M. / ...Authors: Abrahams, K.A. / Chung, C.W. / Ghidelli-Disse, S. / Rullas, J. / Rebollo-Lopez, M.J. / Gurcha, S.S. / Cox, J.A. / Mendoza, A. / Jimenez-Navarro, E. / Martinez-Martinez, M.S. / Neu, M. / Shillings, A. / Homes, P. / Argyrou, A. / Casanueva, R. / Loman, N.J. / Moynihan, P.J. / Lelievre, J. / Selenski, C. / Axtman, M. / Kremer, L. / Bantscheff, M. / Angulo-Barturen, I. / Izquierdo, M.C. / Cammack, N.C. / Drewes, G. / Ballell, L. / Barros, D. / Besra, G.S. / Bates, R.H. |
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History | Deposition | Jun 23, 2016 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 21, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 8, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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