Entry Database : PDB / ID : 5j17 Structure visualization Downloads & linksTitle Solution structure of Ras Binding Domain (RBD) of B-Raf ComponentsSerine/threonine-protein kinase B-raf Details Keywords PROTEIN BINDING / MAPK / PI3KFunction / homology Function and homology informationFunction Domain/homology Component
trehalose metabolism in response to stress / CD4-positive, alpha-beta T cell differentiation / CD4-positive or CD8-positive, alpha-beta T cell lineage commitment / negative regulation of synaptic vesicle exocytosis / head morphogenesis / Signalling to p38 via RIT and RIN / myeloid progenitor cell differentiation / ARMS-mediated activation / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling ... trehalose metabolism in response to stress / CD4-positive, alpha-beta T cell differentiation / CD4-positive or CD8-positive, alpha-beta T cell lineage commitment / negative regulation of synaptic vesicle exocytosis / head morphogenesis / Signalling to p38 via RIT and RIN / myeloid progenitor cell differentiation / ARMS-mediated activation / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / endothelial cell apoptotic process / negative regulation of fibroblast migration / positive regulation of glucose transmembrane transport / establishment of protein localization to membrane / mitogen-activated protein kinase kinase binding / regulation of T cell differentiation / Negative feedback regulation of MAPK pathway / positive regulation of axonogenesis / Frs2-mediated activation / stress fiber assembly / positive regulation of axon regeneration / face development / synaptic vesicle exocytosis / somatic stem cell population maintenance / MAP kinase kinase activity / thyroid gland development / MAP kinase kinase kinase activity / negative regulation of endothelial cell apoptotic process / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of stress fiber assembly / response to cAMP / cellular response to calcium ion / ERK1 and ERK2 cascade / substrate adhesion-dependent cell spreading / cellular response to nerve growth factor stimulus / thymus development / long-term synaptic potentiation / animal organ morphogenesis / Spry regulation of FGF signaling / RAF activation / Signaling by high-kinase activity BRAF mutants / visual learning / MAP2K and MAPK activation / epidermal growth factor receptor signaling pathway / response to peptide hormone / Negative regulation of MAPK pathway / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / MAPK cascade / Signaling by BRAF and RAF1 fusions / cellular response to xenobiotic stimulus / presynapse / positive regulation of peptidyl-serine phosphorylation / T cell differentiation in thymus / T cell receptor signaling pathway / regulation of cell population proliferation / cell body / scaffold protein binding / negative regulation of neuron apoptotic process / Ras protein signal transduction / positive regulation of ERK1 and ERK2 cascade / non-specific serine/threonine protein kinase / protein kinase activity / neuron projection / protein phosphorylation / intracellular membrane-bounded organelle / protein serine kinase activity / protein serine/threonine kinase activity / calcium ion binding / protein-containing complex binding / positive regulation of gene expression / negative regulation of apoptotic process / mitochondrion / ATP binding / identical protein binding / nucleus / plasma membrane / cytosol Similarity search - Function Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain ... Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ubiquitin-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / DGSA-distance geometry simulated annealing DetailsAuthors Dutta, K. / Vasquez-Del Carpio, R. / Aggarwal, A.K. / Reddy, E.P. Funding support United States, 4items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) CA158209 United States Onconova Therapeutics Inc (OCI) United States National Institutes of Health/National Center for Research Resources (NIH/NCRR) CO6RR015495 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P41GM066354 United States
CitationJournal : Cell / Year : 2016Title : A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.Authors: Athuluri-Divakar, S.K. / Vasquez-Del Carpio, R. / Dutta, K. / Baker, S.J. / Cosenza, S.C. / Basu, I. / Gupta, Y.K. / Reddy, M.V. / Ueno, L. / Hart, J.R. / Vogt, P.K. / Mulholland, D. / Guha, ... Authors : Athuluri-Divakar, S.K. / Vasquez-Del Carpio, R. / Dutta, K. / Baker, S.J. / Cosenza, S.C. / Basu, I. / Gupta, Y.K. / Reddy, M.V. / Ueno, L. / Hart, J.R. / Vogt, P.K. / Mulholland, D. / Guha, C. / Aggarwal, A.K. / Reddy, E.P. History Deposition Mar 29, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 5, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2017 Group : Author supporting evidence / Structure summary / Category : entity / pdbx_audit_supportItem : _entity.pdbx_number_of_molecules / _pdbx_audit_support.funding_organizationRevision 1.2 Dec 4, 2019 Group : Author supporting evidence / Data collection / Category : pdbx_audit_support / pdbx_nmr_spectrometerItem : _pdbx_audit_support.funding_organization / _pdbx_nmr_spectrometer.modelRevision 1.3 Jun 14, 2023 Group : Database references / Other / Category : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_dataRevision 1.4 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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