+Open data
-Basic information
Entry | Database: PDB / ID: 5irv | ||||||
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Title | Human cytochrome P450 17A1 bound to inhibitor VT-464 | ||||||
Components | Steroid 17-alpha-hydroxylase/17,20 lyase | ||||||
Keywords | OXIDOREDUCTASE / LYASE/INHIBITOR / Inhibitor complex / LYASE-INHIBITOR complex | ||||||
Function / homology | Function and homology information Defective CYP17A1 causes AH5 / steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase / steroid 17-alpha-monooxygenase activity / : / glucocorticoid biosynthetic process / Androgen biosynthesis / hormone biosynthetic process / Glucocorticoid biosynthesis / androgen biosynthetic process ...Defective CYP17A1 causes AH5 / steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase / steroid 17-alpha-monooxygenase activity / : / glucocorticoid biosynthetic process / Androgen biosynthesis / hormone biosynthetic process / Glucocorticoid biosynthesis / androgen biosynthetic process / sex differentiation / progesterone metabolic process / steroid biosynthetic process / steroid metabolic process / oxygen binding / iron ion binding / axon / neuronal cell body / heme binding / endoplasmic reticulum membrane / endoplasmic reticulum Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.098 Å | ||||||
Authors | Scott, E.E. / Petrunak, E.M. | ||||||
Funding support | United States, 1items
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Citation | Journal: Drug Metab. Dispos. / Year: 2017 Title: Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. Authors: Petrunak, E.M. / Rogers, S.A. / Aube, J. / Scott, E.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5irv.cif.gz | 702.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5irv.ent.gz | 593.4 KB | Display | PDB format |
PDBx/mmJSON format | 5irv.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ir/5irv ftp://data.pdbj.org/pub/pdb/validation_reports/ir/5irv | HTTPS FTP |
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-Related structure data
Related structure data | 5irqC 3swzS C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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