登録情報 データベース : PDB / ID : 4bkf 構造の表示 ダウンロードとリンクタイトル crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 要素EPHRIN TYPE-A RECEPTOR 4 EPHRIN-B3 詳細キーワード TRANSFERASE (転移酵素) / CELL ADHESION (細胞接着) / CELL REPULSION / RECEPTOR CLUSTERING / RECEPTOR CIS INTERACTION / ERYTHROPOETIN-PRODUCING HEPATOCELLULAR RECEPTOR / LBD / SUSHI (寿司) / EGF / FN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
axon choice point recognition / trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission / DH domain binding / : / neuron projection fasciculation / positive regulation of Rho guanyl-nucleotide exchange factor activity / corticospinal tract morphogenesis / regulation of astrocyte differentiation / negative regulation of proteolysis involved in protein catabolic process / : ... axon choice point recognition / trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission / DH domain binding / : / neuron projection fasciculation / positive regulation of Rho guanyl-nucleotide exchange factor activity / corticospinal tract morphogenesis / regulation of astrocyte differentiation / negative regulation of proteolysis involved in protein catabolic process / : / neuron projection guidance / nephric duct morphogenesis / regulation of synapse pruning / fasciculation of sensory neuron axon / fasciculation of motor neuron axon / synapse pruning / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / negative regulation of cellular response to hypoxia / negative regulation of axon regeneration / glial cell migration / negative regulation of axonogenesis / PH domain binding / GPI-linked ephrin receptor activity / regulation of modification of synaptic structure / transmembrane-ephrin receptor activity / regulation of dendritic spine morphogenesis / negative regulation of epithelial to mesenchymal transition / negative regulation of cell adhesion / motor neuron axon guidance / adult walking behavior / adherens junction organization / positive regulation of dendrite morphogenesis / EPH-Ephrin signaling / Ephrin signaling / Somitogenesis / positive regulation of amyloid-beta formation / regulation of axonogenesis / cochlea development / regulation of GTPase activity / EPHA-mediated growth cone collapse / plasma membrane => GO:0005886 / positive regulation of cell adhesion / positive regulation of protein tyrosine kinase activity / negative regulation of long-term synaptic potentiation / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / axon terminus / axonal growth cone / EPHB-mediated forward signaling / T cell costimulation / ephrin receptor binding / hippocampal mossy fiber to CA3 synapse / negative regulation of cell migration / protein tyrosine kinase binding / dendritic shaft / filopodium / 軸索誘導 / postsynaptic density membrane / 接着結合 / Schaffer collateral - CA1 synapse / neuromuscular junction / negative regulation of ERK1 and ERK2 cascade / 受容体型チロシンキナーゼ / peptidyl-tyrosine phosphorylation / cellular response to amyloid-beta / virus receptor activity / cell-cell signaling / negative regulation of neuron projection development / presynaptic membrane / nervous system development / kinase activity / amyloid-beta binding / early endosome membrane / perikaryon / protein tyrosine kinase activity / mitochondrial outer membrane / 樹状突起スパイン / protein autophosphorylation / negative regulation of translation / protein stabilization / 細胞接着 / protein kinase activity / positive regulation of cell migration / 神経繊維 / glutamatergic synapse / 樹状突起 / positive regulation of cell population proliferation / 細胞膜 / ATP binding / identical protein binding / 細胞膜 / 細胞質 類似検索 - 分子機能 Ephrin type-A receptor 4, SAM domain / Ephrin type-A receptor 4, ligand binding domain / Ephrin receptor-binding domain / Ephrin, conserved site / エフリン / エフリン / Ephrin receptor-binding (ephrin RBD) domain signature. / Ephrin receptor-binding (ephrin RBD) domain profile. / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like ... Ephrin type-A receptor 4, SAM domain / Ephrin type-A receptor 4, ligand binding domain / Ephrin receptor-binding domain / Ephrin, conserved site / エフリン / エフリン / Ephrin receptor-binding (ephrin RBD) domain signature. / Ephrin receptor-binding (ephrin RBD) domain profile. / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / フィブロネクチンIII型ドメイン / Cupredoxin / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 4.65 Å 詳細データ登録者 Seiradake, E. / Schaupp, A. / del Toro Ruiz, D. / Kaufmann, R. / Mitakidis, N. / Harlos, K. / Aricescu, A.R. / Klein, R. / Jones, E.Y. 引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2013タイトル : Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses著者 : Seiradake, E. / Schaupp, A. / Del Toro Ruiz, D. / Kaufmann, R. / Mitakidis, N. / Harlos, K. / Aricescu, A.R. / Klein, R. / Jones, E.Y. 履歴 登録 2013年4月24日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年7月3日 Provider : repository / タイプ : Initial release改定 1.1 2013年7月10日 Group : Database references改定 1.2 2013年8月21日 Group : Database references改定 1.3 2015年11月11日 Group : Data collection改定 1.4 2019年4月3日 Group : Data collection / Other / Source and taxonomyカテゴリ : entity_src_gen / pdbx_database_proc / pdbx_database_statusItem : _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval改定 1.5 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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