登録情報 | データベース: PDB / ID: 3llm |
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タイトル | Crystal Structure Analysis of a RNA Helicase |
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要素 | ATP-dependent RNA helicase A |
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キーワード | HYDROLASE (加水分解酵素) / alpha-beta-alpha / Structural Genomics (構造ゲノミクス) / Structural Genomics Consortium / SGC / Activator / ATP-binding / DNA-binding / Helicase (ヘリカーゼ) / Methylation (メチル化) / Nucleotide-binding / Nucleus (Nucleus) / Phosphoprotein / RNA-binding |
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機能・相同性 | 機能・相同性情報
3'-5' DNA/RNA helicase activity / single-stranded 3'-5' DNA helicase activity / CRD-mediated mRNA stability complex / : / regulation of cytoplasmic translation / regulatory region RNA binding / positive regulation of RNA export from nucleus / DNA-templated viral transcription / positive regulation of viral transcription / RISC complex binding ...3'-5' DNA/RNA helicase activity / single-stranded 3'-5' DNA helicase activity / CRD-mediated mRNA stability complex / : / regulation of cytoplasmic translation / regulatory region RNA binding / positive regulation of RNA export from nucleus / DNA-templated viral transcription / positive regulation of viral transcription / RISC complex binding / triplex DNA binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / protein localization to cytoplasmic stress granule / nucleoside triphosphate diphosphatase activity / G-quadruplex DNA unwinding / nuclear stress granule / 3'-5' RNA helicase activity / perichromatin fibrils / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / positive regulation of interleukin-18 production / RNA secondary structure unwinding / alternative mRNA splicing, via spliceosome / RISC-loading complex / regulation of mRNA processing / miRNA-mediated post-transcriptional gene silencing / RISC complex assembly / regulation of defense response to virus by host / positive regulation of cytoplasmic translation / importin-alpha family protein binding / RIP-mediated NFkB activation via ZBP1 / positive regulation of response to cytokine stimulus / siRNA binding / positive regulation of innate immune response / sequence-specific mRNA binding / RISC complex / RNA polymerase binding / DNA duplex unwinding / 3'-5' DNA helicase activity / cellular response to exogenous dsRNA / pyroptotic inflammatory response / RNA polymerase II complex binding / DNA replication origin binding / positive regulation of interferon-alpha production / mRNA transport / RNA stem-loop binding / positive regulation of DNA repair / DNA helicase activity / positive regulation of interferon-beta production / ribonucleoside triphosphate phosphatase activity / mRNA Splicing - Major Pathway / positive regulation of DNA replication / promoter-specific chromatin binding / DNA-templated transcription termination / transcription coregulator activity / PKR-mediated signaling / chromatin DNA binding / positive regulation of inflammatory response / cytoplasmic ribonucleoprotein granule / osteoblast differentiation / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / double-stranded RNA binding / positive regulation of fibroblast proliferation / rhythmic process / マイクロフィラメント / ribosome binding / cellular response to tumor necrosis factor / positive regulation of NF-kappaB transcription factor activity / single-stranded DNA binding / double-stranded DNA binding / protein-containing complex assembly / RNA polymerase II-specific DNA-binding transcription factor binding / DNA複製 / transcription coactivator activity / RNA helicase activity / single-stranded RNA binding / nuclear body / ヘリカーゼ / 炎症 / ribonucleoprotein complex / RNA polymerase II cis-regulatory region sequence-specific DNA binding / 自然免疫系 / mRNA binding / 中心体 / 核小体 / regulation of transcription by RNA polymerase II / ATP hydrolysis activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / RNA binding / 核質 / ATP binding / 生体膜 / metal ion binding / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 DHX9, first double-stranded RNA binding domain / DHX9, second double-stranded RNA binding domain / DHX9, DEXH-box helicase domain / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation ...DHX9, first double-stranded RNA binding domain / DHX9, second double-stranded RNA binding domain / DHX9, DEXH-box helicase domain / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / Double-stranded RNA binding motif / Double-stranded RNA binding motif / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / Double stranded RNA-binding domain (dsRBD) profile. / Double-stranded RNA-binding domain / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / CACODYLATE ION / : / ATP-dependent RNA helicase A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 多波長異常分散 / 解像度: 2.8 Å |
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データ登録者 | Schutz, P. / Karlberg, T. / Collins, R. / Arrowsmith, C.H. / Berglund, H. / Bountra, C. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. ...Schutz, P. / Karlberg, T. / Collins, R. / Arrowsmith, C.H. / Berglund, H. / Bountra, C. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Johansson, A. / Johansson, I. / Kallas, A. / Kraulis, P. / Kotenyova, T. / Kotzsch, A. / Markova, N. / Moche, M. / Nielsen, T.K. / Nordlund, P. / Nyman, T. / Persson, C. / Roos, A.K. / Siponen, M.I. / Svensson, L. / Thorsell, A.G. / Tresaugues, L. / Van Den Berg, S. / Wahlberg, E. / Weigelt, J. / Welin, M. / Wisniewska, M. / Schuler, H.M. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2010 タイトル: Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein. 著者: Schutz, P. / Wahlberg, E. / Karlberg, T. / Hammarstrom, M. / Collins, R. / Flores, A. / Schuler, H. |
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履歴 | 登録 | 2010年1月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年5月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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